The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes
نویسندگان
چکیده
منابع مشابه
Protein translocation across the bacterial cytoplasmic membrane.
About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a ribosome-bound nascent chain by the signal recognition particle (SRP) or by the secretion-dedicated chaperone SecB. Subsequently, they are targeted to the Sec translocase in the cytoplasmic membrane, a multimeric...
متن کاملProtein targeting to the bacterial cytoplasmic membrane.
Proteins that perform their activity within the cytoplasmic membrane or outside this cell boundary must be targeted to the translocation site prior to their insertion and/or translocation. In bacteria, several targeting routes are known; the SecB- and the signal recognition particle-dependent pathways are the best characterized. Recently, evidence for the existence of a third major route, the t...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2021
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00986-20